Phospho-MSK1 (Thr581) Recombinant Rabbit Monoclonal Antibody (MSK1T581-A5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA537014-Each-of-1 | In Stock | ₹ 33,019.00 |
PIMA537014 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,019.00
GST (18%): ₹ 5,943.42
Total Price: ₹ 38,962.42
Antigen
Phospho-MSK1 (Thr581)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O75582, Q8C050
Gene Symbols
Rps6ka5
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG κ
Applications
Flow Cytometry, Western Blot
Clone
MSK1T581-A5
Conjugate
Unconjugated
Gene
Rps6ka5
Gene Alias
3110005L17Rik; 6330404E13Rik; 90 kDa ribosomal protein S6 kinase 5; AI854034; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Msk1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase A5; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5; RLPK; RLSK; Rps6ka5; RSKL; RSK-like protein kinase; S6K-alpha-5
Host Species
Rabbit
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
314384, 73086, 9252
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes
- RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes
- Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin
- Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression
- In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress
- In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.