PIMA515015
AXIN2 Monoclonal Antibody (J.415.10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515015-Each-of-1 | In Stock | ₹ 43,832.50 |
PIMA515015 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,832.50
GST (18%): ₹ 7,889.85
Total Price: ₹ 51,722.35
Antigen
AXIN2
Classification
Monoclonal
Concentration
183 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
Q9Y2T1
Gene Symbols
AXIN2
Immunogen
Synthetic peptide corresponding to residues surrounding Pro566 of human Axin2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Clone
J.415.10
Conjugate
Unconjugated
Gene
AXIN2
Gene Alias
Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8313
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with Axin1
- The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil
- In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin
- Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies
- The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors
- Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.