DKK1 Monoclonal Antibody (2H2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515497-Each-of-1 | In Stock | ₹ 50,240.50 |
PIMA515497 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,240.50
GST (18%): ₹ 9,043.29
Total Price: ₹ 59,283.79
Antigen
DKK1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
O94907
Gene Symbols
DKK1
Immunogen
Purified recombinant fragment of DKK1 expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
22943
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Western Blot
Clone
2H2
Conjugate
Unconjugated
Gene
DKK1
Gene Alias
dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Related Products
Description
- MA5-15497 targets DKK1 in indirect ELISA, WB applications and shows reactivity with Human samples
- The MA5-15497 immunogen is purified recombinant fragment of DKK1 expressed in E
- Coli
- MA5-15497 detects DKK1 which has a predicted molecular weight of approximately 28.7kDa
- DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4
- DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling
- Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system
- LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade
- It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development
- This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.