Metadherin Monoclonal Antibody (2F11C3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515564-Each-of-1 | In Stock | ₹ 49,884.50 |
PIMA515564 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,884.50
GST (18%): ₹ 8,979.21
Total Price: ₹ 58,863.71
Antigen
Metadherin
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 50% glycerol and 0.03% sodium azide
Gene Accession No.
Q86UE4
Gene Symbols
MTDH
Immunogen
Purified recombinant fragment of human Metadherin expressed in E. Coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Clone
2F11C3
Conjugate
Unconjugated
Gene
MTDH
Gene Alias
2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
92140
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA5-15564 targets Metadherin in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples
- The MA5-15564 immunogen is purified recombinant fragment of human Metadherin expressed in E
- Coli
- MA5-15564 detects Metadherin which has a predicted molecular weight of approximately 64kDa
- Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells
- At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex
- Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue
- Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.