HIF-1 beta Monoclonal Antibody (H1beta234), DyLight™ 550, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516015-Each-of-1 | In Stock | ₹ 48,015.50 |
PIMA516015 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,015.50
GST (18%): ₹ 8,642.79
Total Price: ₹ 56,658.29
Antigen
HIF-1 beta
Classification
Monoclonal
Concentration
1.03 mg/mL
Formulation
50mM sodium borate with 0.05% sodium azide
Gene Accession No.
P27540, P41739, P53762, Q9BE97
Gene Symbols
ARNT
Immunogen
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
H1beta234
Conjugate
DyLight 550
Gene
ARNT
Gene Alias
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11863, 25242, 281010, 405, 443285
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.