Phospho-Androgen Receptor (Ser213, Ser210) Monoclonal Antibody (156C135.2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516221-Each-of-1 | In Stock | ₹ 50,863.50 |
PIMA516221 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,863.50
GST (18%): ₹ 9,155.43
Total Price: ₹ 60,018.93
Antigen
Phospho-Androgen Receptor (Ser213, Ser210)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P10275, P15207, P19091, Q9TT90
Gene Symbols
AR
Immunogen
Synthetic peptide corresponding to amino acids 207-221 (GRAREAS*GAPTSSKD) of human androgen receptor, containing the serine 213 phosphorylation.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
156C135.2
Conjugate
Unconjugated
Gene
AR
Gene Alias
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11835, 24208, 367, 403588
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Suggested positive control: IGF-1 stimulated LNCaP
- The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
- The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
- The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
- Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
- The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis
- AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain
- Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
- The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
- Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility
- Mutations in this gene are associated with complete androgen insensitivity (CAIS).