TNFAIP3 Monoclonal Antibody (59A426), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516164-Each-of-1 | In Stock | ₹ 53,578.00 |
PIMA516164 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,578.00
GST (18%): ₹ 9,644.04
Total Price: ₹ 63,222.04
Antigen
TNFAIP3
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P21580, Q60769
Gene Symbols
TNFAIP3
Immunogen
Full length recombinant human A20.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
59A426
Conjugate
Unconjugated
Gene
TNFAIP3
Gene Alias
A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
21929, 683206, 7128
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas
- Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas
- TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity
- Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens
- At least two isoforms of TNFAIP3 are known to exist.