Androgen Receptor Monoclonal Antibody (AR 441), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA513426-Each-of-1 | In Stock | ₹ 54,957.50 |
PIMA513426 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 54,957.50
GST (18%): ₹ 9,892.35
Total Price: ₹ 64,849.85
Antigen
Androgen Receptor
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.
P10275
Gene Symbols
AR
Immunogen
Synthetic peptide corresponding to Human Androgen Receptor aa 299-315
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
AR 441
Conjugate
Unconjugated
Gene
AR
Gene Alias
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
367
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-13426 targets Androgen Receptor in ICC/IF, IHC (P), IP, and WB applications and shows reactivity with human samples
- The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
- The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
- The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
- Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
- The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis
- AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain
- Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
- The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
- Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility
- Mutations in this gene are associated with complete androgen insensitivity (CAIS).