TLR2 Monoclonal Antibody (11G5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516260-Each-of-1 | In Stock | ₹ 50,151.50 |
PIMA516260 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
TLR2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q9QUN7
Gene Symbols
Tlr2
Immunogen
A portion of amino acids 400-450 of murine TLR2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
11G5
Conjugate
Unconjugated
Gene
Tlr2
Gene Alias
CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
24088
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This monoclonal antibody only very weakly detects human TLR2 in Ramos cell lysate and is not recommended for human sample testing
- TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity
- TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B
- TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively
- TLRs are highly conserved from Drosophila to humans and share structural and functional similarities
- The various TLRs exhibit different patterns of expression
- TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB
- TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity
- Ten human homologs of TLRs (TLR1-10) have been described
- TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers
- CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells
- The expression of TLR2 on different cell types are regulated by different immune response modifiers
- For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.