TLR4 Monoclonal Antibody (MTS510), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516213-Each-of-1 | In Stock | ₹ 51,130.50 |
PIMA516213 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,130.50
GST (18%): ₹ 9,203.49
Total Price: ₹ 60,333.99
Antigen
TLR4
Classification
Monoclonal
Concentration
0.43 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q9QUK6
Gene Symbols
TLR4
Immunogen
Ba/F3 cell line expressing mouse TLR4 and MD-2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
MTS510
Conjugate
PE
Gene
TLR4
Gene Alias
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
21898
Content And Storage
4° C, store in dark
Form
Liquid
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Description
- TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity
- TLRs are highly conserved from Drosophila to humans and share structural and functional similarities
- This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes
- Mammalian cells respond to LPS by activating TLR4
- TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria
- TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity
- The various TLRs exhibit different patterns of expression
- Mutations in the TLR4 gene have been associated with differences in LPS responsiveness
- Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain
- TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta
- Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide
- Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.