I-Ab/I-Ad Monoclonal Antibody (25-9-17S), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA517777-Each-of-1 | In Stock | ₹ 22,116.50 |
PIMA517777 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,116.50
GST (18%): ₹ 3,980.97
Total Price: ₹ 26,097.47
Antigen
I-Ab/I-Ad
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene Accession No.
P01921, P06342, P06343, P06344, P06345, P06346, P14483
Gene Symbols
H2-Ab1
Immunogen
C3H.SW splenocytes
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry
Clone
25-9-17S
Conjugate
PE
Gene
H2-Ab1
Gene Alias
Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; IAb; I-Abeta; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
14961
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- MA5-17777 targets I-Ab/I-Ad in FACS applications and shows reactivity with Mouse samples
- The MA5-17777 immunogen is c3H.SW splenocytes
- MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains
- Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes
- First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides
- Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside
- MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells
- CD4 interacts with non-polymorphic residues of MHC class II
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.