PIMA517770
I-Ap Monoclonal Antibody (7-16.17), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA517770-Each-of-1 | In Stock | ₹ 22,116.50 |
PIMA517770 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,116.50
GST (18%): ₹ 3,980.97
Total Price: ₹ 26,097.47
Antigen
I-Ap
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene Accession No.
P04230
Gene Symbols
H2-Eb1
Immunogen
B10.p
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry
Clone
7-16.17
Conjugate
PE
Gene
H2-Eb1
Gene Alias
cell surface glycoprotein; H-2 class II histocompatibility antigen, I-E beta chain; H2Eb; H-2Eb; H2-Eb1; histocompatibility 2, class II antigen E beta; Ia4; Ia-4; I-E beta MHC class II; major histocompatibility complex H-2E beta chain; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
14969
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- MA5-17770 targets I-Ap in FACS applications and shows reactivity with Mouse samples
- The MA5-17770 immunogen is b10.p
- MHC Class II (I-Ap) is a protein complex found on the surface of cells in vertebrates
- Its main function is to present peptides derived from extracellular proteins to T cells for immune recognition
- MHC Class II (I-Ap) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove
- MHC Class II (I-Ap) is primarily restricted to antigen-presenting cells, including dendritic cells, macrophages, and B cells
- These cells are responsible for capturing and processing antigens from the extracellular environment
- Once the antigens are internalized, they are broken down into smaller peptides, which then bind to MHC Class II molecules within the endosomal compartments of these cells
- MHC Class II (I-Ap) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail
- The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane
- The cytoplasmic tail plays a role in intracellular signaling events
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.