PIMA524619
MACC1 Monoclonal Antibody (CL0856), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524619-Each-of-1 | In Stock | ₹ 50,774.50 |
PIMA524619 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,774.50
GST (18%): ₹ 9,139.41
Total Price: ₹ 59,913.91
Antigen
MACC1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q6ZN28
Gene Symbols
MACC1
Immunogen
Recombinant protein corresponding to Human MACC1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry
Clone
CL0856
Conjugate
Unconjugated
Gene
MACC1
Gene Alias
4732474O15Rik; 7A5; Gm267; MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; SH3 domain-containing protein 7a5; SH3BP4L
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
346389
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: FRSGRIAQSM SEANLIDMEA GKLSKSCNIT ECQDPDLLHN WPDAFTLRGN NASKVANPFW NQLSASNPF Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 27%
- MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis
- MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD)
- Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas
- MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion
- Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis
- MACC1 may also be an important therapeutic target for colorectal cancer treatment
- At least two isoforms of MACC1 are known to exist.