PIMA524702
MCU Monoclonal Antibody (CL3576), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524702-Each-of-1 | In Stock | ₹ 53,311.00 |
PIMA524702 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,311.00
GST (18%): ₹ 9,595.98
Total Price: ₹ 62,906.98
Antigen
MCU
Classification
Monoclonal
Concentration
1.00 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q8NE86
Gene Symbols
MCU
Immunogen
Recombinant Human MCU
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Western Blot
Clone
CL3576
Conjugate
Unconjugated
Gene
MCU
Gene Alias
2010012O16Rik; AV064928; C10orf42; Calcium uniporter protein, mitochondrial; Ccdc109a; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; D130073L02Rik; Gm64; HsMCU; MCU; mitochondrial calcium uniporter
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
90550
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: TRQEYVYPEAR DRQYLLFFHK GAKKSRFDLE KYNQLKDAIA QAEMDLKRLR DPLQVHLPLR QIGE Binds to an epitope located within the peptide sequence RDRQYLLFFH as determined by overlapping synthetic peptides
- Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%
- Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria
- Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex)
- Activity is regulated by MICU1 and MICU2
- At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity
- Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways
- Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes
- While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells
- participates in mitochondrial permeability transition during ischemia-reperfusion injury
- Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake
- Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults
- Regulates synaptic vesicle endocytosis kinetics in central nerve terminal
- Involved in antigen processing and presentation.