NOP56 Monoclonal Antibody (CL2603), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524641-Each-of-1 | In Stock | ₹ 53,489.00 |
PIMA524641 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,489.00
GST (18%): ₹ 9,628.02
Total Price: ₹ 63,117.02
Antigen
NOP56
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O00567
Gene Symbols
Nop56
Immunogen
Recombinant protein corresponding to Human NOP56
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
CL2603
Conjugate
Unconjugated
Gene
Nop56
Gene Alias
2310044F10Rik; 56kDa with KKE/D repeat; hypothetical protein 1195; NOL5A; Nop56; NOP56 ribonucleoprotein; NOP56 ribonucleoprotein homolog; nucleolar protein 56; Nucleolar protein 5A; nucleolar protein 5A (56kDa with KKE/D repeat); SCA36; similar to nucleolar protein 5A (56kDa with KKE/D repeat)
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10528
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: EDPSISFSKP KKKKSFSKEE LMSSDLEETA GSTS Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 62%
- Binds to an epitope located within the peptide sequence FSKEELMSSDLEETA as determined by overlapping synthetic peptides
- ErbB 4 (Her-4, c-erbB-4, v-erbB-4) is a member of the class I receptor kinase family
- With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes
- The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains
- ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases)
- ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself
- Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation
- ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum
- Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361
- Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3
- ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.