TRPM4 Monoclonal Antibody (OTI14C3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524916-Each-of-1 | In Stock | ₹ 52,376.50 |
PIMA524916 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,376.50
GST (18%): ₹ 9,427.77
Total Price: ₹ 61,804.27
Antigen
TRPM4
Classification
Monoclonal
Concentration
0.7 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q8TD43
Gene Symbols
TRPM4
Immunogen
Full-length protein expressed in 293T cell transfected with human TRPM4 expression vector
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI14C3
Conjugate
Unconjugated
Gene
TRPM4
Gene Alias
1110030C19Rik; AW047689; Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4; LTrpC4; LTrpC-4; melastatin like 2 protein; melastatin-4; Melastatin-like 2; MLS2s; PFHB1B; transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential ion channel melastatin subgroup member 4; Trpm4; TRPM4B
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
54795
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization
- While it is activated by increase in intracellular Ca2+, it is impermeable to it
- Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane
- It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc
- Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production
- Involved in myogenic constriction of cerebral arteries
- Controls insulin secretion in pancreatic beta-cells
- May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload
- Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization
- Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.