TRPM4 Monoclonal Antibody (OTI10H5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524918-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA524918 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
TRPM4
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q8TD43
Gene Symbols
TRPM4
Immunogen
Full length human recombinant protein of TRPM4 produced in HEK293T cell
Quantity
100μL
Primary or Secondary
Primary
Target Species
Canine, Human, Non-human Primate
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI10H5
Conjugate
Unconjugated
Gene
TRPM4
Gene Alias
1110030C19Rik; AW047689; Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4; LTrpC4; LTrpC-4; melastatin like 2 protein; melastatin-4; Melastatin-like 2; MLS2s; PFHB1B; transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential ion channel melastatin subgroup member 4; Trpm4; TRPM4B
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
484385, 54795
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization
- While it is activated by increase in intracellular Ca2+, it is impermeable to it
- Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane
- It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc
- Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production
- Involved in myogenic constriction of cerebral arteries
- Controls insulin secretion in pancreatic beta-cells
- May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload
- Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization
- Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.