PIMA526806
Protein Z Monoclonal Antibody (OTI4F1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA526806-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA526806 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
Protein Z
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P22891
Gene Symbols
PROZ
Immunogen
Human recombinant protein fragment corresponding to amino acids 115-400 of PROZ produced in E.coli
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI4F1
Conjugate
Unconjugated
Gene
PROZ
Gene Alias
protein Z, vitamin K dependent plasma glycoprotein; protein Z, vitamin K-dependent plasma glycoprotein; PROZ; PZ; vitamin K-dependent protein Z; vitamin K-dependent protein Z precursor variant 1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8858
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PROZ protein Z, vitamin K-dependent plasma glycoprotein
- It is 62 kDa large and 396 amino acids long
- It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain
- It lacks the serine residue that would make it catalytically active as a serine protease
- It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots
- It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy
- It is a glycoprotein
- Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C
- The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces
- The main role of protein Z appears to be the degradation of factor Xa
- This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z
- Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z
- In some studies, deficiency states have been associated with a propensity to thrombosis
- Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.