PIMA529724
LDLR Recombinant Rabbit Monoclonal Antibody (004), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA529724-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA529724 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
LDLR
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P35951
Gene Symbols
LDLR
Immunogen
Recombinant Mouse LDLR Protein (Met1-Arg790)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry
Clone
004
Conjugate
Unconjugated
Gene
LDLR
Gene Alias
FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16835
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Mouse LDLR
- The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands
- Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis
- At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place
- Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia
- Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus
- At least three isoforms of LDL-R are known to exist.