ALAS1 Recombinant Rabbit Monoclonal Antibody (SA70-04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA531972-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA531972 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ALAS1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P13196
Gene Symbols
ALAS1
Immunogen
Recombinant protein within Human Alas1 aa 510-640
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
SA70-04
Conjugate
Unconjugated
Gene
ALAS1
Gene Alias
5'-aminolevulinate synthase 1, 5-aminolevulinate synthase 1, 5-aminolevulinate synthase, nonspecific, mitochondrial, 5-aminolevulinic acid synthase 1, ALAS, ALA-S, ALAS1, Alas-1, ALAS3, ALASH, Alas-h, ALAS-N, aminolevulinate synthase H, aminolevulinate, delta-, synthase 1, aminolevulinic acid synthase 1, delta-ALA synthase 1, delta-ALA synthetase, delta-aminolevulinate synthase 1, MIG4, migration-inducing protein 4, OK/SW-cl.121, succinyl-CoA: glycine C-succinyl transferase
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
211
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA
- It regulates the first and rate-limiting step of heme biosynthetic pathway
- It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme
- It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins
- ALAS1 in liver undergoes negative feedback regulation by heme
- Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression
- ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders
- ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.