HP1 alpha Recombinant Rabbit Monoclonal Antibody (SR44-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532018-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532018 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
HP1 alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P45973, Q61686
Gene Symbols
Cbx5
Immunogen
Recombinant protein within Human HP1 alpha aa 101-191
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SR44-03
Conjugate
Unconjugated
Gene
Cbx5
Gene Alias
2610029O15Rik, antigen p25, C75991, Cbx5, Cbx5 antibody, chromobox 5, chromobox homolog 5, chromobox homolog 5 (HP1 alpha homolog, Drosophila), chromobox protein homolog 5, chromobox-like protein 5, epididymis luminal protein 25, HEL25, heterochromatin protein 1 alpha, heterochromatin protein 1 homolog alpha, heterochromatin protein 1-alpha, HGNC:1555, HP1, HP1 alpha, HP-1 alpha antibody, HP1 alpha homolog, Hp1a, Hp1alpha, HP1-ALPHA, HP1Hs alpha, HP1Hs-alpha, mHP1(alpha)
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
12419, 23468, 300266
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing
- It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure
- High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain
- Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3
- In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.