MLH1 Recombinant Rabbit Monoclonal Antibody (SP08-04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532041-Each-of-1 | In Stock | ₹ 53,088.50 |
PIMA532041 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,088.50
GST (18%): ₹ 9,555.93
Total Price: ₹ 62,644.43
Antigen
MLH1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P40692, P97679, Q9JK91
Gene Symbols
Mlh1
Immunogen
Synthetic peptide within Human MLH1 aa 707-756
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
ChIP Assay, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SP08-04
Conjugate
Unconjugated
Gene
Mlh1
Gene Alias
1110035C23Rik, AI317206, AI325952, AI561766, COCA2, colon cancer, nonpolyposis type 2, DNA mismatch repair protein Mlh1, DNA mismatch repair protein Mlh1-like protein, FCC2, hMLH1, HNPCC, HNPCC2, I79_014127, MGC5172, mismatch repair protein 1, MLH1, MLH-1, mutL homolog 1, mutL homolog 1 (E. coli), mutL homolog 1, colon cancer, nonpolyposis type 2, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), mutL protein homolog 1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17350, 4292, 81685
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- MLH1 is a DNA mismatch repair protein
- The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time
- An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI)
- These defects in DNA repair pathways have been related to human carcinogenesis
- The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC)
- MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process
- It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.