Phospho-ERK1/ERK2 (Thr202,Thr185) Recombinant Rabbit Monoclonal Antibody (SZ2-4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532024-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532024 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Phospho-ERK1/ERK2 (Thr202,Thr185)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P27361, P28482
Gene Symbols
MAPK1, MAPK3
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Thr185 of human Erk2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SZ2-4
Conjugate
Unconjugated
Gene
MAPK1
Gene Alias
12559, 9030612K14Rik, AA407128, AU018647, BcDNA:RE08694, C78273, CG12559, CG12559-PA, CG12559-PC, CG12559-PD, CG12559-PE, CG12559-PG, CG12559-PH, CG12559-PI, CG18732, CT34260, CT39192, DERK, D-ERK, DERK-A, Diphospho-ERK, dm-dpERK, Dmel\CG12559, Dmel_CG12559, DmErk, DmERKA, DmERK-A, DmMAPK, dpERK, dp-ERK, dpERK1, dpMAPK, drosophila ERK, Dsor2, E(sina)7, EC2-1, EK2-1, enhancer of seven in absentia 7, ERK, Erk MAP kinase, Erk/Map kinase, ERK/rolled, Erk1, Erk-1, erk1 erk2, Erk1/2, ERK1b, ERK2, ERK-2, ERKA, ERK-A, ERT1, ERT2, Esrk1, extracellular signal-regulated kinase, extracellular signal-regulated kinase (ERK2), extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, extracellular signal-regulated kinase A, extracellular signal-regulated kinase-1, extracellular signal-regulated kinase-2, extracellular signal-related kinase 1, Extracellular-regulated kinase A, extracellular-signal-regulated kinase 2, Extracellular-signal-related kinase A, EY2-2, fi06b09, GroupI
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5594, 5595
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells
- Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways
- When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well
- Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2
- Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.