ELK1 Recombinant Rabbit Monoclonal Antibody (SU32-05), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532109-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532109 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ELK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
A4GTP4, P19419, P41969
Gene Symbols
ELK1
Immunogen
Synthetic peptide within Human ELK1 aa 378-428
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
SU32-05
Conjugate
Unconjugated
Gene
ELK1
Gene Alias
ELK 1, ELK1, Elk-1, ELK1, ETS transcription factor, ELK1, member of ETS oncogene family, ETS domain-containing protein Elk-1, ETS transcription factor ELK1, ETS-like gene 1, Oncogene Elk1, tyrosine kinase (ELK1) oncogene
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
13712, 2002, 314436
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors
- ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus
- Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1
- ELK1 appears to be a direct target of activated MAP kinase
- Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo
- ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade
- Alternatively spliced transcript variants encoding the same protein have been found for ELK1.