PIMA532780
JAK1 Recombinant Rabbit Monoclonal Antibody (JM75-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532780-Each-of-1 | In Stock | ₹ 51,842.50 |
PIMA532780 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,842.50
GST (18%): ₹ 9,331.65
Total Price: ₹ 61,174.15
Antigen
JAK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P23458, P52332
Gene Symbols
JAK1
Immunogen
Synthetic peptide within Human JAK1 aa 621-670
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Clone
JM75-03
Conjugate
Unconjugated
Gene
JAK1
Gene Alias
AA960307, BAP004, C130039L05Rik, EC 2.7.10.2, Jak1, JAK-1, JAK1A, JAK1B, Janus kinase 1, Janus protein tyrosine kinase 1, JTK3, kinase Jak1, Tyrosine-protein kinase JAK1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16451, 3716, 84598
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways
- Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1
- JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription
- Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner
- Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.