Catenin alpha-1 Recombinant Rabbit Monoclonal Antibody (SC0619), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532216-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532216 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Catenin alpha-1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P26231, P35221
Gene Symbols
CTNNA1
Immunogen
Recombinant protein within Human alpha 1 Catenin aa 1-90
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SC0619
Conjugate
Unconjugated
Gene
CTNNA1
Gene Alias
[a]E-catenin, 102 kDa cadherin-associated protein, 2010010M04Rik, AA517462, AI988031, alpha E catenin, alpha E-catenin, alpha(E)-catenin, alpha-E-catenin, cadherin associated protein, Cadherin-associated protein, CAP102, catenin (cadherin associated protein), alpha 1, catenin (cadherin-associated protein), alpha, catenin (cadherin-associated protein), alpha 1, catenin (cadherin-associated protein), alpha 1, 102kDa, catenin alpha 1, catenin alpha 1 S homeolog, catenin alpha-1, catenin, alpha 1, Catna1, cell-adhesion protein alphaE catenin, ctnna, ctnna1, ctnna1.S, MDPT2, Renal carcinoma antigen NY-REN-13, XELAEV_18020018mg
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
12385, 1495, 307505
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Associates with the cytoplasmic domain of a variety of cadherins
- The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties
- Can associate with both E- and N-cadherins
- Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions
- In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components
- The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments
- May play a crucial role in cell differentiation.