WAVE2 Recombinant Rabbit Monoclonal Antibody (SC66-05), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532235-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532235 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
WAVE2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q8BH43, Q9Y6W5
Gene Symbols
WASF2
Immunogen
Synthetic peptide within Human WASF2 aa 440-485
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
SC66-05
Conjugate
Unconjugated
Gene
WASF2
Gene Alias
AW742646, D4Ertd13e, dJ393P12.2, IMD2, protein WAVE-2, putative Wiskott-Aldrich syndrome protein family member 4, SCAR2, suppressor of cyclic-AMP receptor (WASP-family), verprolin homology domain-containing protein 2, WAS protein family member 2, WAS protein family, member 2, Wasf2, WASF4, WASP family protein member 2, WASP family protein member 4, WASP family Verprolin-homologous protein 2, WAVE2, Wiskott-Aldrich syndrome protein family member 2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10163, 242687, 313024
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization
- The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton
- The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases
- The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac
- The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments
- WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes
- WAVE3 forms a multiprotein complex that links receptor kinases and actin
- Binding to actin occurs through a C-terminal verprolin homology domain in all family members
- The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.