Phospho-SHIP1 (Tyr1020) Recombinant Rabbit Monoclonal Antibody (JJ082-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532455-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532455 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
Phospho-SHIP1 (Tyr1020)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q92835
Gene Symbols
INPP5D
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Tyr1020 of Human SHIP aa 991-1040
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
JJ082-03
Conjugate
Unconjugated
Gene
INPP5D
Gene Alias
7a33, hp51CN, Inositol polyphosphate-5-phosphatase 145 kDa, inositol polyphosphate-5-phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa, inositol polyphosphate-5-phosphatase, 145 kDa, inositol polyphosphate-5-phosphatase, 145kD, inositol polyphosphate-5-phosphatase, 145kDa, Inpp5d, MGC104855, MGC142140, MGC142142, OTTHUMP00000165069, OTTHUMP00000165070, OTTHUMP00000165071, OTTHUMP00000165072, OTTHUMP00000203442, p150Ship, phosphatidylin, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, Phosphatidylinositol-4,5-bisphosphate 5-phosphatase, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5'-phosphatase 1, SH2-containing inositol phosphatase SHIP, SHIP, SHIP1, SHIP-1, signaling inositol polyphosphate 5 phosphatase SIP-145, signaling inositol polyphosphate phosphatase SHIP II, SIP-145, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3635
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains
- Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation
- At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways
- Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival
- Alternate transcriptional splice variants, encoding different isoforms, have been characterized.