Thioredoxin 1 Recombinant Rabbit Monoclonal Antibody (JF101-8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532557-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532557 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Thioredoxin 1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P10599, P10639, P11232
Gene Symbols
TXN, Txn1
Immunogen
Synthetic peptide within Human Thioredoxin aa 78-105
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Clone
JF101-8
Conjugate
Unconjugated
Gene
TXN
Gene Alias
ADF, ATL-derived factor, AW550880, DKFZp686B1993, MGC61975, RP11-427L11.1, SASP, surface-associated sulphydryl protein, testicular tissue protein Li 199, thioredoxin, thioredoxin 1, thioredoxin delta 3, TRDX, TRX, TRX1, Txn, TXN delta 3, Txn1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
116484, 22166, 7295
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells
- Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site
- The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds
- Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor
- The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations
- Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151)
- Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.