CD80 (B7-1) Recombinant Rabbit Monoclonal Antibody (JF100-4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532562-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532562 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CD80 (B7-1)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P33681
Gene Symbols
CD80
Immunogen
Synthetic peptide within Human CD80 aa 246-288
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JF100-4
Conjugate
Unconjugated
Gene
CD80
Gene Alias
Activation B7-1 antigen, B7, B7 protein, B7.1, B71, B7-1, B7-1 protein, B7-1 protein precursor, BB1, B-lymphocyte activation antigen B7, Cd28l, CD28LG, CD28LG1, CD80, Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1), CD80 anitgen, CD80 antigen, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), Cd80 molecule, CD80 protein precursor, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, LAB7, Ly53, Ly-53, MIC17, sCD 80, sCD80, secreted B7-1 protein precursor, soluble CD 80, soluble CD80, T-cell costimulatory molecule, T-cell co-stimulatory protein B7-1, T-lymphocyte activation antigen CD80, TS/A-1, TSA1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
941
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152)
- Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process
- CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes
- The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells
- Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.