53BP1 Recombinant Rabbit Monoclonal Antibody (JA66-11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532653-Each-of-1 | In Stock | ₹ 47,125.50 |
PIMA532653 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,125.50
GST (18%): ₹ 8,482.59
Total Price: ₹ 55,608.09
Antigen
53BP1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P70399, Q12888
Gene Symbols
TP53BP1, Trp53bp1
Immunogen
Synthetic peptide within Human 53BP1 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JA66-11
Conjugate
Unconjugated
Gene
TP53BP1
Gene Alias
53BP1, FLJ41424, m53BP1, MGC138366, murine p53-binding protein, p202, p53-binding protein 1, p53BP1, TDRD30, TP53, TP53-binding protein 1, Tp53bp1, transformation related protein 53 binding protein 1, transformation related protein 53 binding-protein 1, Trp53bp1, tumor protein 53-binding protein, 1, tumor protein p53 binding protein 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
27223, 296099, 7158
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- 53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase
- Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks
- 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.