PRKAR2B Recombinant Rabbit Monoclonal Antibody (JA11-69), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532662-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532662 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
PRKAR2B
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P12369, P31323, P31324
Gene Symbols
Prkar2b
Immunogen
Synthetic peptide within Human PKA 2 beta aa 369-418
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JA11-69
Conjugate
Unconjugated
Gene
Prkar2b
Gene Alias
AI451071, AW061005, cAMP-dependent protein kinase RII-beta regulatory subunit, cAMP-dependent protein kinase type II-beta regulatory chain, cAMP-dependent protein kinase type II-beta regulatory subunit, H_RG363E19.2, Pkarb2, PKARIIbeta, PRKAR2, PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta, protein kinase, cAMP dependent regulatory, type II beta, protein kinase, cAMP-dependent, regulatory subunit type II beta, protein kinase, cAMP-dependent, regulatory, type II, beta, RATDNA, RII(beta), RII-BETA, Type II beta regulatory subunit of cAMP-dependent protein kinase, WUGSC:H_RG363E19.2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19088, 24679, 5577
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- cAMP is a signaling molecule important for a variety of cellular functions
- cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins
- The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits
- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
- Four different regulatory subunits and three catalytic subunits have been identified in humans
- The protein encoded by this gene is one of the regulatory subunits
- This subunit can be phosphorylated by the activated catalytic subunit
- This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells
- Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity
- The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.