PRKAR1A Recombinant Rabbit Monoclonal Antibody (1C3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533190-Each-of-1 | In Stock | ₹ 50,596.50 |
PIMA533190 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
PRKAR1A
Classification
Recombinant Monoclonal
Concentration
0.55 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P10644
Gene Symbols
PRKAR1A
Immunogen
A synthesized peptide derived from human PRKAR1A
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Immunocytochemistry, Western Blot
Clone
1C3
Conjugate
Unconjugated
Gene
PRKAR1A
Gene Alias
1300018C22Rik, ACRDYS1, ADOHR, cAMP-dependent protein kinase regulatory subunit RIalpha, cAMP-dependent protein kinase type I-alpha regulatory chain, cAMP-dependent protein kinase type I-alpha regulatory subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed, CAR, Carney complex type 1, CNC, CNC1, PKR1, PPNAD1, PRKAR1, Prkar1a, protein kinase A type 1a regulatory subunit, protein kinase cAMP-dependent type I regulatory subunit alpha, protein kinase, cAMP dependent regulatory, type 1, alpha, protein kinase, cAMP dependent regulatory, type I, alpha, protein kinase, cAMP-dependent, regulatory subunit type I alpha, protein kinase, cAMP-dependent, regulatory, type I, alpha, RIalpha, RIIA, Tissue-specific extinguisher 1, Tse1, Tse-1
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
5573
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
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Description
- cAMP is a signaling molecule important for a variety of cellular functions
- cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins
- The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits
- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
- Four different regulatory subunits and three catalytic subunits have been identified in humans
- This gene encodes one of the regulatory subunits
- This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids
- Mutations in this gene cause Carney complex (CNC)
- This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2
- A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40)
- Three alternatively spliced transcript variants encoding the same protein have been observed.