Axl Monoclonal Antibody (C4-A8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532897-Each-of-1 | In Stock | ₹ 53,934.00 |
PIMA532897 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,934.00
GST (18%): ₹ 9,708.12
Total Price: ₹ 63,642.12
Antigen
Axl
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.2% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P30530
Gene Symbols
AXL
Immunogen
Recombinant protein with Human UFO aa 10-160
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
C4-A8
Conjugate
Unconjugated
Gene
AXL
Gene Alias
Adhesion-related kinase, AI323647, ARK, AXL, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, AZF1, JTK11, oncogene AXL, sAXL, soluble AXL, Tyro7, Tyrosine-protein kinase receptor UFO, Ufo, ufo oncogene homolog
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
558
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Mouse Monoclonal Antibody AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma
- The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation
- TAM receptors are also involved in phagocytosis of apoptotic cells
- Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies
- In addition, Axl may function as a putative entry receptor for filoviruses
- Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells
- Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C
- Soluble Axl is generated by proteolytic cleavage of the membrane form
- Increased plasma levels may be indicative of inflammation and cancer.