Axl Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA514567-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA514567 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
Axl
Classification
Polyclonal
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P30530
Gene Symbols
AXL
Immunogen
KLH conjugated synthetic peptide between 863-894 amino acids from the C-terminal region of human AXL
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Gene
AXL
Gene Alias
Adhesion-related kinase; AI323647; ARK; AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence/gene; AZF1; JTK11; oncogene AXL; sAXL; soluble AXL; Tyro7; Tyrosine-protein kinase receptor UFO; Ufo; ufo oncogene homolog
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Regulatory Status
RUO
Gene ID (Entrez)
558
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma
- The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation
- TAM receptors are also involved in phagocytosis of apoptotic cells
- Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies
- In addition, Axl may function as a putative entry receptor for filoviruses
- Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells
- Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C
- Soluble Axl is generated by proteolytic cleavage of the membrane form
- Increased plasma levels may be indicative of inflammation and cancer.