PIMA534960
BDNF Monoclonal Antibody (3R7D0), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA534960-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA534960 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
BDNF
Classification
Monoclonal
Concentration
1.06 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
P21237, P23363
Gene Symbols
BDNF
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (P23560)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG2a κ
Applications
Western Blot
Clone
3R7D0
Conjugate
Unconjugated
Gene
BDNF
Gene Alias
abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12064, 24225
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Immunogen sequence: PMKEANIRGQ GGLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKVRP NEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDSKKRIGWR FIRIDTSCVC TLTIKRGR BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family
- BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF
- Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form
- BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons
- Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated
- BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation
- BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain
- Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.