PIMA538753
CD83 Monoclonal Antibody (HB15e), PE-Cyanine5, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA538753-Each-of-1 | In Stock | ₹ 32,307.00 |
PIMA538753 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,307.00
GST (18%): ₹ 5,815.26
Total Price: ₹ 38,122.26
Antigen
CD83
Classification
Monoclonal
Conjugate
PE-Cyanine5
Gene
CD83
Gene Alias
B-cell activation protein; BL11; CD antigen CD83; CD83; CD83 antigen; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); CD83 molecule; cell surface protein HB15; cell-surface glycoprotein; HB15; hCD83; mCD83
Host Species
Mouse
Purification Method
Size-exclusion chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9308
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
HB15e
Formulation
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.
Q01151
Gene Symbols
CD83
Immunogen
Human CD83-transfected Cos cells
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Non-human Primate
Form
Liquid
Related Products
Description
- Do not use after expiration date stamped on vial label
- CD83 cell surface antigen is a 40-45kD glycoprotein expressed by peripheral blood dendritic cells
- Peripheral lymphocytes can be induced to express very low levels of CD83 after culture in agents such as Con A or PHA
- In immunohistology, CD83 is shown to be expressed strongly by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres
- CD83 is also expressed by Langerhan's cells in the skin
- The CD83 antigen is a 186-amino-acid single-chain glycoprotein and this molecule is a member of the immunoglobulin superfamily that is composed of an extracellular V-type Ig-like single domain, a transmembrane region, and a short, 40-amino-acid cytoplasmic tail
- CD83 antigen undergoes extensive post-translational glycosylation, since the determined Mr is twice the predicted size of the core protein
- However, CD83+ cells have a unique cell surface immuno-phenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage
- CD83+ cells coexpress the highest levels of MHC class II molecules, when compared with other leucocyte lineages
- They also co-express T cell markers (CD2, CD5), B cell markers (CD40, CD78), myeloid cell markers (CD13, CD33, CD36), cytokine receptors as well as other cell surface molecules
- Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.