PIMA542630
RGMA Recombinant Rabbit Monoclonal Antibody (2S1B4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA542630-Each-of-1 | In Stock | ₹ 45,790.50 |
PIMA542630 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,790.50
GST (18%): ₹ 8,242.29
Total Price: ₹ 54,032.79
Antigen
RGMA
Classification
Recombinant Monoclonal
Concentration
0.67 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q6PCX7
Gene Symbols
RGMA
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human RGMA (Q96B86).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
2S1B4
Conjugate
Unconjugated
Gene
RGMA
Gene Alias
BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
244058, 308739
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Positive test controls include: Mouse heart, Rat skeletal muscle,Rat heart
- The target is usually found in the following locations: Cell membrane, GPI-anchor, Lipid-anchor
- Immunogen sequence: TAPETFPYET AVAKCKEKLP VEDLYYQACV FDLLTTGDVN FTLAAYYALE DVKMLHSNKD KLHLYERTRD LPGRAAAGLP LAPRPLLGAL VPLLALLPVF C Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system
- Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses
- Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition
- Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway
- It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.