CD35 Recombinant Rabbit Monoclonal Antibody (2A0Q1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA542833-Each-of-1 | In Stock | ₹ 45,790.50 |
PIMA542833 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,790.50
GST (18%): ₹ 8,242.29
Total Price: ₹ 54,032.79
Antigen
CD35
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P17927
Gene Symbols
CR1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1940-2039 of human CD35/CR1 (P17927).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone
2A0Q1
Conjugate
Unconjugated
Gene
CR1
Gene Alias
C3 binding protein; C3b/C4b receptor; C3-binding protein; C3BR; C4BR; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement Component (3b/4b) receptor 1 including Knops blood group system; complement component 3b/4b receptor 1 (Knops blood group); complement receptor type 1; CR1; KN; Knops blood group antigen
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1378
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- The target is usually found in the following locations: Membrane, Single-pass type I membrane protein
- Immunogen sequence: DGYTLEGSPW SQCQADDRWD PPLAKCTSRT HDALIVGTLS GTIFFILLII FLSWIILKHR KGNNAHENPK EVAIHLHSQG GSSVHPRTLQ TNEENSRVLP CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules
- CD35 protein mediates cellular binding to particles and immune complexes that have activated complement
- The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa
- CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation
- CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils
- Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis
- Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria
- Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized
- An additional secreted form of CD35 have also been described but has not been fully characterized.