PIMA543966
Amphiregulin Monoclonal Antibody (A6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA543966-Each-of-1 | In Stock | ₹ 15,290.20 |
PIMA543966 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,290.20
GST (18%): ₹ 2,752.236
Total Price: ₹ 18,042.436
Antigen
Amphiregulin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
P15514
Gene Symbols
AREG
Immunogen
Recombinant protein Amphiregulin. The antigen corresponds to amino acid range 20-100 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
A6
Conjugate
Unconjugated
Gene
AREG
Gene Alias
amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
374
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF
- The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor
- Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR
- These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin
- All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds
- AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta
- AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.