Androgen Receptor Recombinant Rabbit Monoclonal Antibody (PO00-29), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544654-Each-of-1 | In Stock | ₹ 42,720.00 |
PIMA544654 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
Androgen Receptor
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P10275, P15207
Gene Symbols
AR
Immunogen
Synthetic peptide within Human Androgen Receptor aa 300-400 (N terminal).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
PO00-29
Conjugate
Unconjugated
Gene
AR
Gene Alias
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
24208, 367
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
- The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
- The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
- Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
- The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis
- AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain
- Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
- The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
- Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility
- Mutations in this gene are associated with complete androgen insensitivity (CAIS).