PREB Recombinant Rabbit Monoclonal Antibody (JE64-56), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544683-Each-of-1 | In Stock | ₹ 42,720.00 |
PIMA544683 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
PREB
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q9HCU5
Gene Symbols
Preb
Immunogen
Recombinant protein within human PREB aa 81-230/417.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
JE64-56
Conjugate
Unconjugated
Gene
Preb
Gene Alias
C85705; mammalian guanine nucleotide exchange factor mSec12; PREB; prolactin regulatory binding-element protein; prolactin regulatory element binding; prolactin regulatory element binding protein; prolactin regulatory element-binding protein; Sec12
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10113
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Prolactin (PRL) expression in the pituitary is limited to specific cells
- Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development
- The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression
- The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins
- A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif
- Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells
- Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.