alpha Synuclein Monoclonal Antibody (10H7), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA545841-Each-of-1 | In Stock | ₹ 40,317.00 |
PIMA545841 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
alpha Synuclein
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
9.1mM sodium bicarbonate, 9.44mM PBS with 123mM ethanolamine, 581mM DMSO and no preservative; pH 7.4
Gene Accession No.
O55042, P37377, P37840
Gene Symbols
SNCA
Immunogen
Mouse alpha synuclein aggregate
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone
10H7
Conjugate
FITC
Gene
SNCA
Gene Alias
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
20617, 29219, 6622
Content And Storage
4° C, store in dark
Isotype
IgG1
Related Products
Description
- A 1:1,000 dilution of MA5-45841 was sufficient for detection of Alpha Synuclein in 15 μg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.∣Binds within the 101-130 aa region of human alpha synuclein, determined using Dot blot and ELISA with corresponding peptides
- Detects approximately 14 kDa band corresponding to Alpha synuclein
- Band at approximately 40 kDa is a trimer
- Does not detect truncated alpha Synuclein (aa 1-114) Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein
- These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking
- Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways
- Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease
- Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease
- Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene
- Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.