PIMA547043
SARS-CoV-2 NSP1 Recombinant Rabbit Monoclonal Antibody (HL1435), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547043-Each-of-1 | In Stock | ₹ 40,317.00 |
PIMA547043 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
SARS-CoV-2 NSP1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Target Species
Virus
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
HL1435
Conjugate
Unconjugated
Gene Alias
COVID19 Nsp1; COVID-19 Nsp1; SARS-CoV-2 Nonstructural Protein 1; SARS-CoV2 NSP1; SARS-COV-2 NSP1
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of SARS-CoV-2 (COVID-19) nsp1. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- Inhibits host translation by interacting with the 40S ribosomal subunit (PubMed:32680882)
- Nsp1 C terminus binds to and obstructs ribosomal mRNA entry tunnel (PubMed:32680882)
- Thereby inhibits antiviral response triggered by innate immunity or interferons (PubMed:32680882)
- The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation
- Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation
- By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.