TDP-43 Monoclonal Antibody (3H8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547322-Each-of-1 | In Stock | ₹ 1,49,520.00 |
PIMA547322 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,49,520.00
GST (18%): ₹ 26,913.60
Total Price: ₹ 1,76,433.60
Antigen
TDP-43
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.
Q13148, Q921F2
Gene Symbols
TARDBP
Immunogen
Full length recombinant human TDP43 expressed in and purified from E. coli.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Bovine, Equine, Human, Mouse, Porcine, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone
3H8
Conjugate
Unconjugated
Gene
TARDBP
Gene Alias
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
100051482, 100739753, 230908, 23435, 298648, 540632
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR
- Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"ee; splice site
- A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U)
- TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.