Tyrosine Hydroxylase Monoclonal Antibody (4H2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547336-Each-of-1 | In Stock | ₹ 1,49,520.00 |
PIMA547336 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,49,520.00
GST (18%): ₹ 26,913.60
Total Price: ₹ 1,76,433.60
Antigen
Tyrosine Hydroxylase
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.
P04177, P07101, P24529
Gene Symbols
TH
Immunogen
Full length human TH as expressed in and purified from E. coli
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone
4H2
Conjugate
Unconjugated
Gene
TH
Gene Alias
dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
21823, 25085, 7054
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine
- In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4)
- BH4 binds to the TH catalytic domain, resulting in enzymatic activity
- Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated
- These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains
- TH is also responsible for the conversion of L-tyrosine to L-dopa
- TH plays a key role in the physiology of adrenergic neurons
- The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.