TPMT Recombinant Rabbit Monoclonal Antibody (JE64-09), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544759-Each-of-1 | In Stock | ₹ 42,720.00 |
PIMA544759 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
TPMT
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O55060, P51580, Q9Z0T0
Gene Symbols
TPMT
Immunogen
Synthetic peptide within human TPMT aa 101-150/245.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone
JE64-09
Conjugate
Unconjugated
Gene
TPMT
Gene Alias
AW106912; HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMTD; truncated thiopurine methyltransferase
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
22017, 690050, 7172
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine
- Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency)
- TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs
- These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation
- Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.