Phospho-Paxillin (Tyr31) Monoclonal Antibody (M102), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547633-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA547633 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
Phospho-Paxillin (Tyr31)
Classification
Monoclonal
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P49023, Q66H76, Q8VI36
Gene Symbols
PXN
Immunogen
Clone M102 was generated from phospho-Paxillin (Tyr-31) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 31 of human paxillin. This human sequence is highly conserved in rat and mouse paxillin.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Western Blot
Clone
M102
Conjugate
Unconjugated
Gene
PXN
Gene Alias
adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19303, 360820, 5829
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG1
Related Products
Description
- This antibody detects a 72kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of pervanadate treated A431 cells, but not in A431 control cells
- Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL
- The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion
- Paxillin associates tightly with FAK and Crk through its SH2 domain
- This interaction is independent of the extracellular matrix
- Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.