PIMA547739
Syntaphilin Monoclonal Antibody (M371), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547739-Each-of-1 | In Stock | ₹ 40,851.00 |
PIMA547739 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,851.00
GST (18%): ₹ 7,353.18
Total Price: ₹ 48,204.18
Antigen
Syntaphilin
Classification
Monoclonal
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
B5DF41, O15079, Q80U23
Gene Symbols
SNPH
Immunogen
Clone M371 was generated from a sequence corresponding to amino acids in the N-terminal region of human syntaphilin. This sequence has high homology to mouse and rat syntaphilin.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Western Blot
Clone
M371
Conjugate
Unconjugated
Gene
SNPH
Gene Alias
6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
241727, 296267, 9751
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG1
Related Products
Description
- This antibody detects a 70 kDa* protein corresponding to the molecular mass of Syntaphilin on SDS-PAGE immunoblots of adult mouse brain
- Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait
- Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25
- Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis
- Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis
- Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria
- This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function
- Multiple isoforms are known to exist.