PIPA520529
Syntaphilin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520529-Each-of-1 | In Stock | ₹ 46,146.50 |
PIPA520529 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,146.50
GST (18%): ₹ 8,306.37
Total Price: ₹ 54,452.87
Antigen
Syntaphilin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SNPH
Gene Alias
6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
241727, 296267, 9751
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
B5DF41, O15079, Q80U23
Gene Symbols
SNPH
Immunogen
A 16 amino acid peptide from near the center of human Syntaphilin.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE
- A suggested positive control is rat brain tissue lysate
- PA5-20529 can be used with blocking peptide PEP-0649
- Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait
- Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25
- Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis
- Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis
- Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria
- This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function
- Multiple isoforms are known to exist.